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Life Sci. 1987 Jan 26;40(4):367-74.

The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer--poloxamine 908.

Abstract

Colloidal carriers injected intravenously are normally removed rapidly and efficiently by the liver and this represents a major barrier to drug targeting. By coating model microspheres and emulsions with a block co-polymer (poloxamine) it has been possible to keep the carrier circulating in the vascular compartment with little or no uptake by the reticuloendothelial system.

PMID:
3807638
DOI:
10.1016/0024-3205(87)90138-x
[Indexed for MEDLINE]

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