Format

Send to

Choose Destination
Brain Res. 1986 Nov 19;398(1):215-9.

Magnesium-free medium activates seizure-like events in the rat hippocampal slice.

Abstract

The effect of magnesium-free medium on the electrical activity in CA3 of the rat hippocampal slice was examined. Magnesium removal resulted in the development of spontaneous and triggered interictal-like bursting, followed by spontaneous ictal-like events and finally periodic clustered bursts. The ictal-like events consisted of a tonic firing phase and a phase of clustered burst discharges resembling the tonic and clonic phases of seizures. The return to normal medium resulted in spontaneous and triggered interictal-like bursts.

PMID:
3801897
DOI:
10.1016/0006-8993(86)91274-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center