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Biochim Biophys Acta. 1987 Feb 14;917(2):337-40.

Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor.


Reduced glutathione and other compounds with free -SH groups promoted the oxidation of low-density lipoprotein (LDL) in the absence of cells in Ham's F-10 medium. In contrast, compounds in which the thiol groups were oxidized or blocked were ineffective in oxidizing LDL. Thiol-induced modification of LDL did not occur in media lacking in redox metals. It is suggested that thiols react with redox metal, generating thiol- and oxygen-derived free radicals that promote modification of LDL.

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