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Arthritis Rheum. 1986 Dec;29(12):1501-9.

Female sex hormones suppress development of collagen-induced arthritis in mice.

Abstract

We have previously reported that male DBA/1 mice are more susceptible to collagen-induced arthritis than are females. Here we report that oophorectomy makes female mice as susceptible to collagen arthritis as are normal males. Induction of collagen-induced arthritis in mice is a T cell-dependent process. The role of female sex hormones in modulating T cell-dependent autoimmune diseases is discussed.

PMID:
3801072
DOI:
10.1002/art.1780291212
[Indexed for MEDLINE]

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