Send to

Choose Destination
Scand J Rheumatol. 1986;15(3):297-301.

Degradation of bovine articular cartilage proteoglycans in vitro. The effect of Bacteroides gingivalis.


The black-pigmented Bacteroides gingivalis has previously been isolated from periodontal pockets and been shown capable of inflicting advanced tissue damage. Its effect on the degradation of articular cartilage proteoglycans has not previously been known. In these experiments it was demonstrated that under aerobic conditions the anaerobic microbe B. gingivalis is very potent in degrading the proteoglycans of fresh articular cartilage. It is even more potent in the presence of fetal calf serum (FCS) than in its absence. When the cartilage has been frozen/thawed there is still a slight enhancement of the degradation by B. gingivalis, but when the cartilage has been devitalized and de-enzymed by heat, the cartilage-degrading capacity of B. gingivalis is totally abolished. However, addition to the cartilage cultures of filtered conditioned medium from B. gingivalis inhibits in some degree the degradation of articular cartilage proteoglycans. It is therefore suggested that the great cartilage-degrading ability of Bacteroides gingivalis shown in this culture system could be due to its ability to degrade proteinase inhibitors.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center