Chewing-gum preservative induced toxidermic vasculitis

Allergy. 1986 Sep;41(7):546-8. doi: 10.1111/j.1398-9995.1986.tb00342.x.

Abstract

This paper reports the case of a young female patient who presented with a cutaneous urticarial disseminated eruption. Drug-induced side effects were eliminated, and the only recent dietary change was the regular use of chewing-gums containing chlorophylla (E140), menthol and BHT (butylhydroxytoluene). Immunohistological analysis of a cutaneous lesion revealed signs of vasculitis. Within 1 week after stopping chewing gum, the eruption subsided. Oral provocation tests at 4-day intervals confirmed the responsibility of BHT by the reinduction of the cutaneous signs after a few hours.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Butylated Hydroxytoluene / immunology
  • Chewing Gum / adverse effects*
  • Female
  • Food Preservatives / adverse effects*
  • Humans
  • Urticaria / immunology*
  • Vasculitis / immunology*

Substances

  • Chewing Gum
  • Food Preservatives
  • Butylated Hydroxytoluene