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Mol Cell Biol. 1986 Jul;6(7):2734-7.

DNA-mediated transfer of a human gene required for low-density lipoprotein receptor expression and for multiple Golgi processing pathways.

Abstract

Transfection of a hamster cell mutant with human DNA corrected both the low-density lipoprotein receptor-deficient phenotype and the multiple glycosylation defects of the cells. Independently transfected colonies contained a small set of common human DNA fragments. These fragments may correspond to the human analog of a single gene required for several different Golgi processing pathways.

PMID:
3785210
PMCID:
PMC367833
[Indexed for MEDLINE]
Free PMC Article

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