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J Med Chem. 1986 Nov;29(11):2273-80.

Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 1. Hydrazines.

Abstract

The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamazepine.

PMID:
3783589
[Indexed for MEDLINE]
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