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Am J Ophthalmol. 1986 Nov 15;102(5):650-6.

Treatment of trilateral retinoblastoma with vincristine and cyclophosphamide.

Abstract

Current therapy for patients with trilateral retinoblastoma, consisting primarily of surgical intervention and radiotherapy, has resulted in no long-term survivors. The use of adjuvant chemotherapy has not improved this outcome. After observing a tumor response to cyclophosphamide in a patient with suprasellar retinoblastoma, we treated a subsequent patient with trilateral retinoblastoma with both vincristine and cyclophosphamide. Objective tumor regression resulted. Although the tumor ultimately progressed in both patients, these findings suggest that vincristine and cyclophosphamide are active in patients with intracranial (trilateral) retinoblastoma.

PMID:
3777087
DOI:
10.1016/0002-9394(86)90540-4
[Indexed for MEDLINE]

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