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Eur J Cancer Clin Oncol. 1986 Jul;22(7):863-9.

Impaired DNA-repair synthesis in lymphocytes of breast cancer patients.

Abstract

UV-C light induced DNA-repair synthesis was studied in unstimulated lymphocytes of 41 female patients (aged 33-83 years) with invasive breast cancer and of 27 healthy women (aged 37-68 years). As a parameter for the determination of the DNA-repair synthesis the incorporation of [3H] thymidine was taken in the presence of 2 mM hydroxyurea (HU). The [3H] thymidine incorporation levels were reduced in 20 of the 41 patients and in only 3 of the 27 controls. This difference between the two groups was significant. An impaired DNA-repair synthesis might be involved in the etiology of breast cancer in some patients.

PMID:
3770043
DOI:
10.1016/0277-5379(86)90375-5
[Indexed for MEDLINE]

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