Diagnostically one differentiates neoplastic and non neoplastic forms of inappropriate TSH-secretion characterized by increased TSH levels with a parallel rise in peripheral thyroid hormone parameters. Surgery is the treatment of choice in cases of TSH secreting pituitary tumors. In this paper different regims of medication are described in a patient with non neoplastic inappropriate TSH secretion. This 39-year-old woman underwent unsuccessful therapy both with bromocriptine and d-thyroxine. Finally a persistent (so far 4 months) TSH-suppression treatment with TRIAC brought lasting success to the same patient.