Abstract
K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM.
MeSH terms
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Actinomycetales / metabolism
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Animals
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Bacteria / drug effects
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Calmodulin / antagonists & inhibitors
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Carbazoles / isolation & purification*
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Carbazoles / pharmacology
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Fermentation
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Indole Alkaloids
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Mice
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Phosphodiesterase Inhibitors / pharmacology
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Protein Kinase C / antagonists & inhibitors*
Substances
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Calmodulin
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Carbazoles
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Indole Alkaloids
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Phosphodiesterase Inhibitors
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staurosporine aglycone
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Protein Kinase C