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Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide.


Urine of twenty hospital workers was monitored for the excretion of the cytostatic drug cyclophosphamide using GC-MSD. The drug was found to be present above the detection limit of 0.5 microgram/24 h urine in five cases. A clear relationship between cyclophosphamide handling and the detectability of excretion existed. This method developed can be of use for biological monitoring studies directed toward the finding of exposure hazards.

[Indexed for MEDLINE]

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