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Anal Biochem. 1986 Jul;156(1):220-2.

Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions.

Abstract

Water-soluble carbodiimides are frequently employed in coupling or conjugation reactions, e.g., to link a peptide immunogen to a carrier protein. However, their utility is limited by low coupling yields obtained under some conditions. We have found that addition of N-hydroxysulfosuccinimide to such reactions can greatly enhance the yields obtained.

PMID:
3740412
DOI:
10.1016/0003-2697(86)90176-4
[Indexed for MEDLINE]

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