Inhibition of proliferative activity by cyclic dipeptides: spirocyclic derivatives of 1-aminocyclopentane-carboxylic acid

Toxicol Lett. 1986 Jun;31(3):189-93. doi: 10.1016/0378-4274(86)90125-6.

Abstract

The antiproliferative activity of spirocyclic cyclodipeptides containing 1-aminocyclopentanecarboxylic acid (Acp) was investigated and compared with Pro-Leu-Gly-NH2 (MIF), cyclo(Gly-Leu) and cyclo (Sar-Sar), a compound with denaturing activity, employing the chick embryonic caudal morphogenetic system. Out of the compounds tested, MIF and cyclo(Acp-Ala) appear to exhibit the least inhibitory activity on growth.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acids / toxicity*
  • Animals
  • Cell Division / drug effects*
  • Chick Embryo
  • Cycloleucine / analogs & derivatives
  • Cycloleucine / toxicity*
  • Dipeptides
  • Structure-Activity Relationship

Substances

  • Amino Acids
  • Dipeptides
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane