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Biophys J. 1986 Jun;49(6):1223-7.

A test of the stochastic theory of stem cell differentiation.

Abstract

Stochastic theories of stem cell renewal are shown to predict turnover of intestinal crypts. While I found ample evidence of production of new crypts from direct in vivo studies in adult mice, I failed to find evidence of crypt loss. Thus, it would appear that the simple stochastic models may not provide an adequate theory of control of intestinal stem cell function.

PMID:
3719076
PMCID:
PMC1329706
DOI:
10.1016/S0006-3495(86)83751-1
[Indexed for MEDLINE]
Free PMC Article

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