Genitourinary Cancer: Updates on Treatments and Their Impact on the Kidney

Semin Nephrol. 2022 Nov;42(6):151344. doi: 10.1016/j.semnephrol.2023.151344. Epub 2023 May 10.

Abstract

Genitourinary cancers are diverse in their presentation, prevalence, and mortality risk. Although there have been significant advancements in medical (eg, immune checkpoint inhibitors and tyrosine kinase inhibitors) and surgical treatments of genitourinary cancers, patients are still at risk for chronic kidney disease, hypertension, and electrolyte derangements in the short and long term. In addition, pre-existing kidney disease may increase the risk of developing some genitourinary cancers. This review focuses on the kidney-related effects of treatments for renal cell carcinoma and bladder and prostate cancers.

Keywords: Genitourinary cancer; bladder; immune checkpoint inhibitor; kidney; prostate; tyrosine kinase inhibitor.

Publication types

  • Review

MeSH terms

  • Carcinoma, Renal Cell* / epidemiology
  • Carcinoma, Renal Cell* / therapy
  • Humans
  • Kidney / pathology
  • Kidney Neoplasms* / pathology
  • Kidney Neoplasms* / therapy
  • Male
  • Prostatic Neoplasms* / pathology
  • Prostatic Neoplasms* / therapy
  • Urogenital Neoplasms* / therapy