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J Antimicrob Chemother. 1986 Apr;17(4):409-13.

Beta-lactam antibiotics increase the frequency of plasmid transfer in Staphylococcus aureus.

Abstract

The transfer of a plasmid specifying tetracycline resistance between different derivatives of Staphylococcus aureus by phage mediated conjugation was enhanced 100- to 1000-fold by exposure of the culture to subinhibitory concentrations of beta-lactam agents. A variety of other antibiotics, including vancomycin and teicoplanin, had no such effect. The enhanced frequency of transfer was probably due to the formation of large bacterial aggregates.

PMID:
3710955
[PubMed - indexed for MEDLINE]
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