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Eur J Pharmacol. 1979 May 1;55(3):323-6.

Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors.

Abstract

3H-Prazosin binding to membranes from rat brain is saturable, Bmax, 77 fmol/mg protein, of high affinity, KD, 0.28 nM and with a drug specificity indicating that it labels alpha-adrenergic receptors. The ranking of alpha-antagonists for these binding sites suggests that 3H-prazosin may be useful in identifying a subpopulation of alpha-receptors (alpha1) in the central nervous system.

[Indexed for MEDLINE]

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