Survival and repair of potentially lethal radiation damage in confluent vascular smooth muscle cell cultures

Radiother Oncol. 1986 Feb;5(2):159-63. doi: 10.1016/s0167-8140(86)80170-0.

Abstract

Confluent cultures of rat aortic smooth muscle cells demonstrated dose-dependent potentially lethal damage repair (PLDR), with an average repair factor of 4 for a 10 Gy dose. PLDR occurred with a half-time of 2 hours and was nearly maximal by 8 h. Among other factors, PLDR may contribute to the radioresistance of large blood vessels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aorta
  • Cell Line
  • Cell Survival / radiation effects
  • Cells, Cultured
  • Dose-Response Relationship, Radiation
  • Male
  • Muscle, Smooth, Vascular / pathology
  • Muscle, Smooth, Vascular / radiation effects*
  • Radiation Dosage
  • Radiation Injuries, Experimental / pathology*
  • Rats
  • Rats, Inbred Strains