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J Hyg (Lond). 1986 Apr;96(2):143-51.

The protection of infant mice from colonization with Campylobacter jejuni by vaccination of the dams.

Abstract

Intraperitoneal vaccination of female mice, before mating, with a whole cell, heat-killed (62 degrees C) vaccine of Campylobacter jejuni allowed the mother to confer immunity to her young, challenged orally 4-6 days after birth with the homologous strain. There was no protection against a strain of another serotype. Heating the vaccine to 100 degrees C destroyed its protective properties. A vaccine prepared from an aflagellate variant of the original strain was as protective as the original vaccine against challenge with the flagellated strain. Anti-flagellar serum antibody titres of the dams did not correlate with protection of their young.

PMID:
3701036
PMCID:
PMC2129651
DOI:
10.1017/s0022172400065918
[Indexed for MEDLINE]
Free PMC Article

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