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J Steroid Biochem. 1987;27(1-3):115-21.

Steroid hormone receptor localization in the nuclear matrix: interaction with acceptor sites.

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Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.


The nuclear matrix is a conceptually attractive candidate for the site in the nucleus where steroid hormone-receptor complexes might interact to modulate DNA structure and function. We have demonstrated that in sex steroid target tissues a major proportion (50-100%) of the high affinity and steroid-specific receptors that become associated with the nucleus following hormonal stimulation are localized in the nuclear matrix. Direct cell-free binding assays confirm that this localization is due to the presence of specific acceptor sites in the matrix to which steroid-receptor complexes bind with high affinity and tissue specificity, and is not the result of spurious binding. The nuclear matrix appears to be a major site of hormone receptor binding in the nucleus, and this situation is consistent with the known ability of steroid hormones to stimulate gene transcription, a process which also appears to occur in association with the nuclear matrix.

[Indexed for MEDLINE]

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