Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Affiliations

• ¹ William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.
• ² Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.
• ³ Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
• ⁴ University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
• ⁵ Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
• ⁶ Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
• ⁷ Dept. of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
• ⁸ Maastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.
• ⁹ Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.
• ¹⁰ Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, UK.
• ¹¹ Institute of Cardiovascular Sciences, University of College London, London, UK.
• ¹² Aragon Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain and Center of Biomedical Research Network, Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain.
• ¹³ Sorbonne Universite, INSERM, UMR-S1166, Research Unit on Cardiovascular Disorders, Metabolism and Nutrition, Team Genomics & Pathophysiology of Cardiovascular Disease, Paris, 75013, France.
• ¹⁴ ICAN Institute for Cardiometabolism and Nutrition, Paris, 75013, France.
• ¹⁵ Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• ¹⁶ Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
• ¹⁷ McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• ¹⁸ Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
• ¹⁹ Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
• ²⁰ Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
• ²¹ Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
• ²² Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• ²³ MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.
• ²⁴ Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
• ²⁵ Emerge, Emerging Diseases and Climate Change Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, 15152, Peru.
• ²⁶ Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
• ²⁷ Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
• ²⁸ Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
• ²⁹ Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec, QC, Canada.
• ³⁰ Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
• ³¹ Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
• ³² Julius Global Health, University Utrecht Medical Center, Utrecht, the Netherlands.
• ³³ Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
• ³⁴ Usher Institute, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.
• ³⁵ Health Data Research UK, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.
• ³⁶ Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
• ³⁷ Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.
• ³⁸ Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
• ³⁹ Cardiothoracovascular Department, Division of Cardiology, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy.
• ⁴⁰ Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France.
• ⁴¹ Laboratory of Excellence GENMED (Medical Genomics), Paris, France.
• ⁴² Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France.
• ⁴³ Department of Data and Data Support, Region Zealand, 4180, Sorø, Denmark.
• ⁴⁴ Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.
• ⁴⁵ Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
• ⁴⁶ Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
• ⁴⁷ Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
• ⁴⁸ Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
• ⁴⁹ Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
• ⁵⁰ Department of Epidemiology, University of Washington, Seattle, WA, USA.
• ⁵¹ Center for Clinical and Translational Science, Ohio State Medical Center, Columbus, OH, USA.
• ⁵² Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands.
• ⁵³ Instituto René Rachou, fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
• ⁵⁴ Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, København, Denmark.
• ⁵⁵ Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• ⁵⁶ Institute of Health and Wellbeing, School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
• ⁵⁷ Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
• ⁵⁸ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
• ⁵⁹ Department of Neurology, University of Lübeck, Lübeck, Germany.
• ⁶⁰ Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.
• ⁶¹ Labormedizinisches zentrum Dr. Risch, Vaduz, Liechtenstein.
• ⁶² Faculty of Medical Sciences, Private University in the Principality of Liechtenstein, Triesen, Liechtenstein.
• ⁶³ Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland.
• ⁶⁴ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• ⁶⁵ Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Nansha District, Guangzhou, China.
• ⁶⁶ Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston Salem, NC, USA.
• ⁶⁷ Dept. of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
• ⁶⁸ Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany.
• ⁶⁹ NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
• ⁷⁰ Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
• ⁷¹ Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.
• ⁷² Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
• ⁷³ MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.
• ⁷⁴ Netherlands Heart Institute, Utrecht, the Netherlands.
• ⁷⁵ Durrer Center for Cardiovascular Research, Amsterdam, the Netherlands.
• ⁷⁶ Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, the Netherlands.
• ⁷⁷ Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands, Leiden, the Netherlands.
• ⁷⁸ Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
• ⁷⁹ Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
• ⁸⁰ Department of Health Systems and Population Health, University of Washington, Seattte, WA, USA.
• ⁸¹ Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil, Belo Horizonte, Minas Gerais, Brazil.
• ⁸² Cardiology Service and Telehealth Center, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Belo Horizonte, Minas Gerais, Brazil.
• ⁸³ Departments of Pediatrics and Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
• ⁸⁴ Department of Cardiology, Heart and Lung Division, University Medical Center Utrecht, Utrecht, the Netherlands.
• ⁸⁵ Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• ⁸⁶ Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
• ⁸⁷ Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
• ⁸⁸ Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
• ⁸⁹ APHP, Cardiology Department, Pitié-Salpêtrière Hospital, Paris, 75013, France.
• ⁹⁰ APHP, Département de Génétique, Centre de Référence Maladies Cardiaques Héréditaires, Pitié-Salpêtrière Hospital, Paris, 75013, France.
• ⁹¹ Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
• ⁹² Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
• ⁹³ Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. tereshl@ccf.org.
• ⁹⁴ Department of Medicine, Cardiovascular Division, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. tereshl@ccf.org.
• ⁹⁵ William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.
• ⁹⁶ NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.