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Br J Cancer. 1987 Oct;56(4):395-400.

Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.

Author information

1
Radiobiology, Cross Cancer Institute, Edmonton, Alberta, Canada.

Abstract

Polyclonal antibodies have been raised in rabbits to a haemocyanin adduct of a reductively-activated, fluorinated analogue of misonidazole. Fluorescence immunohistochemical studies show that the polyclonal antibodies bind to spheroid sections and tumour sections in patterns similar to those revealed by autoradiographic studies with a tritium-labelled derivative of the fluorinated misonidazole analogue.

PMID:
3689657
PMCID:
PMC2001823
[Indexed for MEDLINE]
Free PMC Article

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