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Biochem Biophys Res Commun. 1987 Oct 29;148(2):653-7.

Inhibition of protein kinase C activity by the Leishmania donovani lipophosphoglycan.

Author information

1
Department of Biochemistry, University of Kentucky Medical Center, Lexington 40536.

Abstract

Purified lipophosphoglycan from Leishmania donovani was found to inhibit the activity of protein kinase C isolated from rat brain. Protein kinase C inhibition by lipophosphoglycan was continuous for 30 minutes. The glycoconjugate was a competitive inhibitor with respect to diolein, a noncompetitive inhibitor with respect to phosphatidylserine, and had no significant effect on protein kinase M and protein kinase A. A possible physiological role of lipophosphoglycan as a negative effector of protein kinase C is suggested.

PMID:
3689364
DOI:
10.1016/0006-291x(87)90926-0
[Indexed for MEDLINE]

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