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Ophthalmology. 1987 Nov;94(11):1503-8.

Anterior ischemic optic neuropathy. IX. Cup-to-disc ratio and its role in pathogenesis.

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W.K. Kellogg Eye Center, University of Michigan, Ann Arbor.


The optic disc appearance in the normal fellow eye of 126 patients with nonarteritic anterior ischemic optic neuropathy (n-AION) was compared with the discs in 23 patients with arteritic AION (a-AION) and 122 normal subjects. The number of discs with no cup was significantly greater (P less than 0.001) and the number of discs with a large cup was significantly fewer (P less than 0.001) in the n-AION group compared to the other two groups. No significant differences were found in cup size between the a-AION and normal groups. The pathogenesis of n-AION appears to be multifactorial. There is overwhelming evidence that ischemia is the primary factor. The size of the optic disc also plays a role, probably through a compressive effect at the level of the lamina cribrosa on axons subjected to ischemia. In contrast, a-AION occurs from posterior ciliary artery occlusion and disc size is not a factor.

[Indexed for MEDLINE]

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