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Br J Pharmacol. 1987 Oct;92(2):429-35.

A study on the effect of a single dose of tamoxifen on uterine hyperaemia and growth in the rat.

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Postgraduate School of Studies in Pharmacology, University of Bradford, West Yorkshire.


1 The effect of a single subcutaneous dose of tamoxifen on the rat uterotrophic response was investigated. 2 The parameters examined were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights and the concentrations of cytosolic and nuclear oestrogen receptors. 3 Tamoxifen or its metabolites proved to be capable of eliciting a uterotrophic response of 35-42 days duration. The changes seen in uterine blood flow and weight are discussed in relation to oestrogen receptor distribution.

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