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Behav Brain Res. 1987 Oct;26(1):57-62.

Intravenous cocaine-induced place preference: attenuation by haloperidol.

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1
Department of Pharmacology, Medical School, University of Athens, Greece.

Abstract

Cocaine reward was demonstrated by establishing a conditioned place preference (CPP) to a distinctive location paired with cocaine administered either intravenously (i.v., 0.5 mg/kg) or intraperitoneally (i.p., 10 mg/kg). Significant i.p. or i.v. cocaine CPP was observed following the second conditioning trial. Haloperidol (0.2 mg/kg) pretreatment disrupted CPP induced by i.v., but not i.p., cocaine. The haloperidol effect built up over successive trials. The involvement of dopaminergic transmission in i.v. cocaine-induced CPP is discussed.

PMID:
3675835
[Indexed for MEDLINE]
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