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Am J Ophthalmol. 1987 Nov 15;104(5):494-501.

Topical fibronectin in the treatment of persistent corneal epithelial defects and trophic ulcers.

Author information

1
Hilles Immunology Laboratory, Massachusetts Eye and Ear Infirmary, Boston.

Abstract

Six patients with persistent corneal epithelial defects that failed to improve with standard therapy were treated with topical fibronectin in a phase I uncontrolled trial. Fibronectin was purified from autologous plasma by affinity chromatography and administered topically, 0.5 mg/ml five times a day, for three weeks. Complete reepithelialization was achieved in five patients: three healed three to 17 days after initiation of treatment while two healed one to two weeks after discontinuation of topical fibronectin. No side effects were observed. Over a follow-up period of three to 18 months, two recurrences were noted.

PMID:
3674183
DOI:
10.1016/s0002-9394(14)74107-8
[Indexed for MEDLINE]

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