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Nature. 1987 Nov 19-25;330(6145):221-6.

The structure of an oligo(dA).oligo(dT) tract and its biological implications.

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1
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Abstract

Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A.T base pairs shows that this region possesses special structural features, including a system of bifurcated hydrogen bonds, which explains some of the properties of this simple homopolymer.

PMID:
3670410
DOI:
10.1038/330221a0
[Indexed for MEDLINE]
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