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Nature. 1987 Nov 12-18;330(6144):132-7.

cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.

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  • 1Department of Cardiovascular Research, Genentech, Inc., South San Francisco, California 94080.

Abstract

Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.

PMID:
3670400
DOI:
10.1038/330132a0
[PubMed - indexed for MEDLINE]
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