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J Pharmacokinet Biopharm. 1987 Jun;15(3):225-39.

A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: a double-site model for drug absorption.

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1
U.E.R. de Mathématiques, Université Paul Sabatier, Toulouse, France.

Abstract

Equal doses of veralipride have been given to 12 healthy volunteers by three different administrations--intravenous infusion, oral solution, and oral capsules--in a randomized cross-over design. After the intake of the solution, but not after infusion or capsules, two maximum plasma concentrations have been observed and interpreted, according to a double-site model for drug absorption.

PMID:
3668801
[Indexed for MEDLINE]
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