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Clin Exp Pharmacol Physiol. 1987 Mar;14(3):263-6.

Effects of neuropeptide Y on left ventricular function in the conscious rabbit.

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  • 1Department of Medicine, Flinders Medical Centre, South Australia.


1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1-30 micrograms/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 micrograms/kg. Beyond 10 micrograms/kg there are only slight effects on heart rate or peak LV dP/dt.

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