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Pharmacol Res Commun. 1987 Jun;19(6):429-40.

The genetic animal model of reflex epilepsy in the Mongolian gerbil: differential efficacy of new anticonvulsive drugs and prototype antiepileptics.

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1
Gödecke Research Institute, Freiburg, FRG.

Abstract

Four new anticonvulsive drugs were compared to four prototype antiepileptics regarding their differential efficacy, i.e. against tonic-clonic, myoclonic, and minor seizures, in reflex epilepsy in genetically epileptic gerbils. We distinguished at least three types of drugs: Phenytoin and ralitoline selectively prevented tonic-clonic seizures; the other drugs tested were active against all seizure types. However, carbamazepine and AHR-11748 were predominantly active against tonic-clonic seizures, whereas phenobarbital, valproate, gabapentin, and zonisamide equipotently suppressed both tonic-clonic and myoclonic seizures.

PMID:
3659116
DOI:
10.1016/0031-6989(87)90082-8
[Indexed for MEDLINE]

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