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Nucleic Acids Res. 1987 Sep 25;15(18):7395-410.

The relationships between the 5' end repeats and the largest members of the L1 interspersed repeated family in the mouse genome.

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CNRS (CRBM-LP 8402), INSERM U.249, Institut de Biologie, Montpellier, France.


Analysis of a few large L1 elements has revealed two types of tandem repeats at the 5' end: A and F. In this study, the relationships between these repeats and a series of large L1 elements has been analysed. Most of cloned L1 repeats were shown to lack either A or F sequences at their 5' ends. F sequences are found less frequently associated than A sequences to the 5' ends of L1 and an evolutionary comparison shows that the A type was introduced more recently during the evolution of the mouse genome than the F type.

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