Considerations for Left Atrial Appendage Occlusion During Cardiac Surgery

Cardiovasc Drugs Ther. 2023 Oct;37(5):1011-1019. doi: 10.1007/s10557-022-07415-y. Epub 2022 Dec 23.

Abstract

Atrial fibrillation is associated with an increased risk of stroke secondary to thrombus formation in the left atrial appendage. Left atrial appendage occlusion (LAAO) is an effective method of reducing the risk of stroke in patients with atrial fibrillation. Although LAAO does not remove the requirement for anticoagulation, it reduces the risk of stroke when compared to anticoagulation alone. We critically analyze the data on LAAO in cardiac surgery. We also discuss the methods of LAAO, the risks of LAAO, and patient populations that could benefit from LAAO. We discuss high-level evidence that LAAO at the time of cardiac surgery reduces the risk of stroke in patients with a history of atrial fibrillation. In patients without a history of atrial fibrillation undergoing cardiac surgery, we suggest that LAAO should be considered in select patients at high risk of atrial fibrillation and stroke, when technically feasible.

Keywords: Atrial fibrillation; Cardiac surgery; Coagulation; Left atrial appendage occlusion; Stroke.

Publication types

  • Review

MeSH terms

  • Anticoagulants
  • Atrial Appendage* / diagnostic imaging
  • Atrial Appendage* / surgery
  • Atrial Fibrillation* / complications
  • Atrial Fibrillation* / diagnosis
  • Atrial Fibrillation* / surgery
  • Cardiac Surgical Procedures* / adverse effects
  • Cardiac Surgical Procedures* / methods
  • Humans
  • Stroke* / diagnosis
  • Stroke* / epidemiology
  • Stroke* / etiology
  • Treatment Outcome

Substances

  • Anticoagulants