Send to

Choose Destination
See comment in PubMed Commons below
Brain Res Bull. 1987 Jul;19(1):135-9.

The hypothalamic suprachiasmatic nuclei: circadian patterns of vasopressin secretion and neuronal activity in vitro.

Author information

  • 1Department of Physiology and Biophysics, University of Illinois, Urbana 61801.


The suprachiasmatic nuclei (SCN) are intrinsic pacemakers which organize circadian rhythms in mammals. When the SCN of Long-Evans rats are surgically isolated and perifused in vitro, they retain the ability to express a 24 hr rhythm of neuronal firing rate. We find that the SCN are also capable of secreting the peptide vasopressin (VP) in a circadian pattern. The pattern of VP secretion is similar to that of SCN neuronal electrical activity measured during perfusate collection. The temporal profile of VP levels in SCN perfusate parallels that seen in cerebrospinal fluid, suggesting that the SCN might be both the pacemaker and a secretory contributor to this rhythm.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center