Format

Send to

Choose Destination
Virology. 1987 Jan;156(1):171-6.

Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins.

Abstract

Ultrathin section and surface replica electron microscopy were applied in combination with immunoelectron microscopy to elucidate the fine structure of HIV. The shell of the tubular core shows p24 antigenicity, while p17 is located at the inner leaflet of the lipid membrane. The virus particle is studded with 70-80 protrusions. These knobs have a diameter of 15 nm, a height of 9 nm, and are probably arranged in a T = 7 I symmetry. The major envelope protein gp120 is spontaneously shed from the viral surface. A possible role of released gp120 in pathogenesis is discussed.

PMID:
3643678
DOI:
10.1016/0042-6822(87)90449-1
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center