Spatiotemporal Bayesian estimation of the number of under-reported COVID-19 cases in Victoria Australia

PeerJ. 2022 Oct 21:10:e14184. doi: 10.7717/peerj.14184. eCollection 2022.

Abstract

Having an estimate of the number of under-reported cases is crucial in determining the true burden of a disease. In the COVID-19 pandemic, there is a great need to quantify the true disease burden by capturing the true incidence rate to establish appropriate measures and strategies to combat the disease. This study investigates the under-reporting of COVID-19 cases in Victoria, Australia, during the third wave of the pandemic as a result of variation in geographic area and time. It is aimed to determine potential under-reported areas and generate the true picture of the disease in terms of the number of cases. A two-tiered Bayesian hierarchical model approach is employed to estimate the true incidence and detection rates through Bayesian model averaging. The proposed model goes beyond testing inequality across areas by looking into other covariates such as weather, vaccination rates, and access to vaccination and testing centres, including interactions and variations between space and time. This model aims for parsimony yet allows a broader range of scope to capture the underlying dynamic of the reported COVID-19 cases. Moreover, it is a data-driven, flexible, and generalisable model to a global context such as cross-country estimation and across time points under strict pandemic conditions.

Keywords: Bayesian model averaging; Detection probability; Incidence; Logit model; Poisson regression; Robust logistic regression; Trend models; Under-reported cases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bayes Theorem
  • COVID-19* / epidemiology
  • Humans
  • Pandemics
  • SARS-CoV-2
  • Victoria / epidemiology

Grants and funding

Dinah Jane Lope was supported by RMIT University with the RMIT Research Stipend Scholarship for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.