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Neurobiol Aging. 1987 Jul-Aug;8(4):346-7.

'Increased calcium-current' hypothesis of brain aging.

Abstract

Based on evidence that high Mg2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca2+-dependent K+ currents, it is proposed that an underlying cause of altered Ca2+ homeostasis during brain aging may be an increased membrane conductance to Ca2+. An apparent Ca2+-mediated inactivation of Ca2+ current, which was recently described in hippocampus, could account for some of the contradictions in the literature.

PMID:
3627350
DOI:
10.1016/0197-4580(87)90074-1
[Indexed for MEDLINE]

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