Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer

Cells. 2022 Sep 26;11(19):3003. doi: 10.3390/cells11193003.

Abstract

Intracellular calcium (Ca2+) concentration ([Ca2+]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca2+]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca2+ signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca2+ signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca2+ signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery.

Keywords: Ca2+ signals; cervical cancer; development; occurrence; prognosis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium Channels / metabolism
  • Calcium Signaling
  • Calcium* / metabolism
  • Female
  • Humans
  • Uterine Cervical Neoplasms* / drug therapy
  • Uterine Cervical Neoplasms* / pathology

Substances

  • Calcium Channels
  • Calcium

Grants and funding

Supported partly by the Ministry of Science and Technology (2019YFA0802600), National Nature and Science Foundation of China (82271724, 81873841, 81741024, and 81401244), Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program, Medical and Industrial Integration Collaborative Innovation Research Project (SLJ202012), and Clinical Trial Institution Capacity Enhancement Project (SLT202003). Jiangsu provincial key research and development plan of science and technology department (BE2018669), General Programs of Jiangsu Commission of Health (M2021087), and Nature and Science Foundation of Jiangsu (BK20221243).