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Exp Eye Res. 1987 May;44(5):663-75.

Kinetic effects of metal ion chelating reagents and their analogues on bovine lens aldehyde dehydrogenase.

Abstract

The chelating agents 1,10-phenanthroline and 2,2'-dipyridyl gave partial inhibition of the bovine lens aldehyde dehydrogenase, which was fully reversible and competitive towards acetaldehyde. The non-chelating compounds, 1,7-phenanthroline, 4,7-phenanthroline and 4,4'-dipyridyl gave total competitive inhibition, and significant activation at saturating substrate and coenzyme concentrations, in a manner similar to cyanide. All five isomers prevented the binding of the coenzyme NAD+, the non-chelating phenanthroline compounds being the most effective. An overall mechanism for inhibition by single and bidentate ligands is proposed.

PMID:
3622646
DOI:
10.1016/s0014-4835(87)80137-9
[Indexed for MEDLINE]

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