Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1146-53.

Evidence for a direct role of the DNA polymerase gamma in the replication of the human mitochondrial DNA in vitro.

Abstract

Indirect experiments suggest that DNA polymerase gamma is involved in the mitochondrial DNA replication process. This report describes an in vitro mitochondrial DNA replication assay directed by the origin of replication of the Heavy strand mt DNA. The assay requires all four dNTP, rNTP and an ATP regenerating system. Nuclease digestion experiments show that specific events occur at the mt origin of replication. Antibodies raised against the purified DNA polymerase gamma inhibit the DNA replication reaction.

PMID:
3619920
DOI:
10.1016/0006-291x(87)90767-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center