Orotic acid excretion in some wild-type strains of Escherichia coli K-12

J Bacteriol. 1978 Nov;136(2):825-7. doi: 10.1128/jb.136.2.825-827.1978.

Abstract

During rapid growth, the excretion of pyrimidines, predominantly uracil, is a common phenomenon in procaryotes and eucaryotes. In Escherichia coli, some K-12 strains excrete orotic acid and not uracil. This is caused by a mutation in the pyrF gene.

MeSH terms

  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Escherichia coli / metabolism*
  • Genes
  • Mutation
  • Orotic Acid / metabolism*
  • Orotidine-5'-Phosphate Decarboxylase / genetics
  • Uracil / metabolism

Substances

  • Uracil
  • Orotic Acid
  • Orotidine-5'-Phosphate Decarboxylase