Abstract
During rapid growth, the excretion of pyrimidines, predominantly uracil, is a common phenomenon in procaryotes and eucaryotes. In Escherichia coli, some K-12 strains excrete orotic acid and not uracil. This is caused by a mutation in the pyrF gene.
MeSH terms
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Escherichia coli / genetics
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Escherichia coli / growth & development
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Escherichia coli / metabolism*
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Genes
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Mutation
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Orotic Acid / metabolism*
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Orotidine-5'-Phosphate Decarboxylase / genetics
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Uracil / metabolism
Substances
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Uracil
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Orotic Acid
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Orotidine-5'-Phosphate Decarboxylase