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J Antimicrob Chemother. 1987 May;19(5):679-83.

Penetration of clofoctol into human lung.

Abstract

The disposition of clofoctol was determined in plasma and lung tissue from 34 patients undergoing pulmonary resection for lung cancer. Clofoctol 1.5 g was given as a rectal suppository; samples of plasma and pulmonary tissue were collected between 15 and 270 min post-dose. Plasma and lung peak concentrations of the drug were 38.07 +/- 0.73 mg/l and 93.13 +/- 6.68 mg/kg at 30 and 90 min, respectively. Mean values for areas under the concentration-time curve and half-life for plasma and lung were 80.91 mg/l/h, 229.65 mg/h, and 1.18 h and 1.21 h, respectively. Tissue to plasma ratios were 0.85 +/- 0.06, 3.82 +/- 0.21 and 6.19 +/- 0.63 at 30, 90 and 180 min post-dose, respectively. Clofoctol is well absorbed from the rectum and accumulates in lung tissue. This may explain its efficacy in bacterial respiratory infections.

PMID:
3610901
DOI:
10.1093/jac/19.5.679
[Indexed for MEDLINE]

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