NTRK3 mutation in secretory carcinoma of the parotid gland: A Case report

Fahad AlKaabba; Abdurahman Alloghbi; Yazeed Deajim; Mohamad W Sukkari; Mir Yousufuddin Ali Khan; Ammar Sukari

doi:10.1002/ccr3.6243

NTRK3 mutation in secretory carcinoma of the parotid gland: A Case report

Clin Case Rep. 2022 Sep 5;10(9):e6243. doi: 10.1002/ccr3.6243. eCollection 2022 Sep.

Authors

Fahad AlKaabba¹, Abdurahman Alloghbi^{2

3}, Yazeed Deajim², Mohamad W Sukkari⁴, Mir Yousufuddin Ali Khan⁵, Ammar Sukari³

Affiliations

¹ Department of Medicine University of Maryland Medical Center Baltimore MD USA.
² College of Medicine King Khalid University Abha Saudi Arabia.
³ Department of Oncology Karmanos Cancer Institute, Wayne State University Detroit Michigan USA.
⁴ Faculty of Medicine University of Aleppo Aleppo Syria.
⁵ Department of Pathology, Detroit Medical Center Wayne State University Detroit Michigan USA.

Abstract

Mammary analog secretory carcinoma (MASC) is a newly described carcinoma with a molecular hallmark of ETV6-NTRK3 fusion that promotes oncogenesis. While MASC histopathology was well-studied in the literature, clinical behavior remains unstudied. We present a 22-year-old man with painless parotid mass, which was diagnosed as salivary gland cancer, MASC subtype.

Keywords: case report; mammary analog secretory carcinoma; salivary gland carcinoma.

Publication types

Case Reports