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FEBS Lett. 1987 Aug 17;220(2):288-90.

Acidification of the interior of Ehrlich ascites tumor cells by nigericin inhibits DNA synthesis.

Abstract

In Ehrlich ascites carcinoma cells, acidification of the cytoplasm down to pH 6.2-6.3 arrests DNA synthesis. Such acidification can be obtained by decreasing the pH outside the cell or, alternatively, by addition of a micromolar concentration of the K+/H+ antiporter nigericin. Thus, nigericin may be regarded as a new type of cytostatic, the effect of which is mediated by alteration of the intracellular pH.

PMID:
3609324
DOI:
10.1016/0014-5793(87)80831-1
[Indexed for MEDLINE]
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