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Biochem Pharmacol. 1987 Aug 15;36(16):2633-6.

The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani.

Abstract

Several alkyl phosphorylcholines and related derivatives were tested against Leishmania donovani amastigotes in mouse peritoneal macrophages in vitro and ED50 values were determined in the range of 1-12 microM. The three alkyl phosphorylcholines tested against L. donovani in BALB/c mice were active, an ED50 of 12.8 mg/kg/day X 5 was ascertained for one compound, but an alkyl phosphorylethanolamine was inactive.

PMID:
3606662
DOI:
10.1016/0006-2952(87)90543-0
[Indexed for MEDLINE]

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