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Nature. 1987 May 28-Jun 3;327(6120):293-7.

Prevalence of ras gene mutations in human colorectal cancers.

Abstract

A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

PMID:
3587348
DOI:
10.1038/327293a0
[Indexed for MEDLINE]

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