Ten patients with peritoneal mesothelioma were treated at the Joint Center for Radiation Therapy between 1968 and 1985. Six of the ten patients remained free of disease at 19+ to 78+ months after diagnosis. The six patients received sequential surgical debulking, combination chemotherapy, and whole-abdomen irradiation. Four patients not treated with this multimodality approach died with disease. This approach may have an impact on the natural course of peritoneal mesothelioma, and warrants further study.